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目的分析采用抗氧化治疗老年糖尿病性骨质疏松的临床效果。方法选择本院2014年1月—2015年3月收治的75例老年糖尿病性骨质疏松患者作为研究对象,随机分为常规组38例和抗氧化组37例。常规组患者给予常规降糖、补钙治疗,抗氧化组患者在常规组的基础上联合抗氧化治疗。对比分析两组患者治疗效果、治疗前后空腹血糖(fasting blood glucose,FBG)、餐后2小时血糖(postprandial 2 hours blood glucose,2 h PBG)、糖化血红蛋白(glycosylated hemoglobin,Hb A1c)、骨源性碱性磷酸酶(bone alkaline phosphatase,BAP)、骨钙素(bone gla protein,BGP)、腰椎L2-4骨密度(bone mineral density,BMD)、视觉模拟量表(visual analogue scale,VAS)评分的差异。计量资料组间比较采用t检验,组内比较采用配对t检验,计数资料采用χ~2检验,P<0.05为差异有统计学意义。结果抗氧化组患者治疗总有效率为94.59%,明显优于常规组的73.68%,差异有统计学意义(P<0.05)。抗氧化组患者FBG、2h PBG、Hb A1c、腰椎L2~4 BMD、BGP、BAP、VAS评分分别为(7.67±1.81)、(9.18±2.71)mmol/L、(6.22±2.59)%、(0.99±0.05)g/cm2、(6.28±1.12)、(10.28±1.12)μg/L、(2.51±0.12)分,均较治疗前的(13.21±3.55)、(16.37±4.72)mmol/L、(11.35±1.92)%、(0.72±0.06)g/cm2、(4.85±0.76)、(12.85±3.66)μg/L、(7.42±1.21)分明显改善,差异均有统计学意义(均P<0.05)。干预后,抗氧化组各指标均明显优于常规组[(9.25±2.41)、(11.43±5.29)mmol/L、(8.33±1.94)%、(0.80±0.04)g/cm2、(5.08±1.26)、(11.58±2.26)μg/L、(3.58±0.21)分],差异均有统计学意义(均P<0.05)。结论采用抗氧化治疗老年糖尿病性骨质疏松效果确切,可在有效降糖控糖的同时,提高BMD,减轻患者疼痛感,值得推广。
Objective To analyze the clinical effect of anti-oxidative treatment on senile diabetic osteoporosis. Methods Seventy-five elderly diabetic patients with osteoporosis admitted to our hospital from January 2014 to March 2015 were selected and randomly divided into routine group (n = 38) and anti-oxidation group (n = 37). Conventional patients given conventional hypoglycemic, calcium treatment, anti-oxidation group of patients on the basis of the conventional combination of anti-oxidative therapy. The therapeutic effects of two groups were compared before and after treatment, fasting blood glucose (FBG), postprandial 2h blood glucose (2h PBG), glycosylated hemoglobin (Hb A1c) Bone alkaline phosphatase (BAP), bone gla protein (BGP), lumbar spine L2-4 bone mineral density (BMD), visual analogue scale (VAS) difference. Measurement data were compared between groups using t test, the group was compared using paired t test, count data usingχ ~ 2 test, P <0.05 for the difference was statistically significant. Results The total effective rate of the anti-oxidation group was 94.59%, which was significantly better than that of the conventional group (73.68%), the difference was statistically significant (P <0.05). The levels of FBG, 2h PBG, Hb A1c, L2-4 BMD, BGP, BAP and VAS in anti-oxidation group were 7.67 ± 1.81, 9.18 ± 2.71 mmol / L, 6.22 ± 2.59% and 0.99 (13.21 ± 3.55) and (16.37 ± 4.72) mmol / L, respectively (P <0.05) g / cm2, (6.28 ± 1.12) and (10.28 ± 1.12) μg / 11.35 ± 1.92), (0.72 ± 0.06) g / cm2, (4.85 ± 0.76) and (12.85 ± 3.66) μg / L and (7.42 ± 1.21) respectively, with statistical significance ). After intervention, the indexes of anti-oxidation group were significantly better than that of the conventional group [(9.25 ± 2.41), (11.43 ± 5.29) mmol / L, (8.33 ± 1.94)%, (0.80 ± 0.04) g / ), (11.58 ± 2.26) μg / L and (3.58 ± 0.21) points, respectively, with significant difference (all P <0.05). Conclusion Antioxidant treatment of elderly diabetic osteoporosis with exact effect, can be effective in controlling glucose and lowering blood sugar, while increasing BMD, reduce pain in patients, it is worth promoting.