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目的:观察复方甘草酸苷联合还原型谷胱甘肽治疗酒精性肝病的疗效。方法:65例酒精性肝病患者随机分为治疗组36例和对照组29例。2组均给予保肝等常规治疗,对照组在常规治疗基础上给予复方甘草酸苷注射液60 mL+质量分数5%葡萄糖注射液250 mL静脉滴注,1次/d;治疗组在对照组治疗基础上给予还原型谷胱甘肽1.8 g+质量分数10%葡萄糖注射液250 mL静脉滴注,1次/d;2组疗程均为4周。比较2组疗效、肝功能指标改善情况。结果:治疗组总有效率88.9%,对照组总有效率65.5%,2组比较差异有统计学意义(P<0.05);治疗组肝功能改善情况优于对照组(P<0.05)。结论:复方甘草酸苷联合还原型谷胱甘肽治疗酒精性肝病疗效确切,安全性好。
Objective: To observe the curative effect of compound glycyrrhizin combined with reduced glutathione on alcoholic liver disease. Methods: Sixty-five patients with alcoholic liver disease were randomly divided into treatment group (36 cases) and control group (29 cases). Two groups were given routine treatment such as liver protection. The control group received 250 mL compound glycyrrhizin injection and 250 mL 5% glucose injection once a day on the basis of routine treatment. In the control group, Based on the given glutathione 1.8 g + 10% glucose injection 250 mL intravenous infusion, 1 / d; 2 courses were 4 weeks. Compare the two groups of efficacy, liver function improvement. Results: The total effective rate was 88.9% in the treatment group and 65.5% in the control group. The difference between the two groups was statistically significant (P <0.05). The improvement of liver function in the treatment group was better than that in the control group (P <0.05). Conclusion: Compound glycyrrhizin combined with reduced glutathione for the treatment of alcoholic liver disease is effective and safe.