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采用比较基因杂交(CGH)检测了2例睾丸生殖细胞肿瘤及1例非睾丸疾病(前列腺癌)的睾丸组织,以研究CGH在实体瘤的应用和睾丸肿瘤的分子遗传学特性。结果表明,CGH具有其它遗传学方法所不具备的特点,如1p32-36、Xp12-22放大的发现等。对CGH方法的原理及意义进行了探讨。
Two cases of testicular germ cell tumor and one case of non-testicle disease (prostate cancer) were examined by comparative gene hybridization (CGH) to study the application of CGH in solid tumors and the molecular genetic characteristics of testicular tumors. The results showed that CGH has the characteristics of other genetic methods do not have, such as 1p32-36, Xp12-22 amplification and so on. The principle and significance of CGH method are discussed.