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目的:观察胃溃疡患者应用兰索拉唑治疗前后的血浆多种因子表达的影响。方法:选取2013年1月~2014年5月期间来我院求诊的胃溃疡患者90例,观察胃溃疡患者治疗前与治疗4周后的血浆丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)、内皮素-1(ET-1)的变化情况。结果:胃溃疡患者在服用兰索拉唑后,血浆MDA、SOD、NO及ET-1的水平都发生了很大的变化,P<0.05。结论:兰索拉唑在治疗胃溃疡的过程中有很高的临床治疗价值,值得进行推广应用。
Objective: To observe the effect of lansoprazole on the expression of plasma multi-factor in patients with gastric ulcer. Methods: 90 gastric ulcer patients admitted to our hospital from January 2013 to May 2014 were selected to observe the changes of plasma malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO) and endothelin-1 (ET-1) were measured. Results: The levels of plasma MDA, SOD, NO and ET-1 in patients with gastric ulcer after taking lansoprazole greatly changed, P <0.05. Conclusion: Lansoprazole in the treatment of gastric ulcer in the process of high clinical value, it is worth to promote the use.