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血清透明质酸(HA)及层粘连蛋白(LN)均与肝炎肝硬变的发生相关,为了进一步了解HA和LN与肝炎后肝硬变所致门静脉高压的确切关系,我们对458例肝硬变患者进行了对比观察,报告如下。 1 临床资料 458例肝炎肝硬变病人系本院1994年1月～1997年12月住院和门诊病人,符合1995年北京会议所修订的《病毒性肝炎防治方案》分型诊断标准。全部病人分为两组,门脉内径>1.4cm者为甲组,共193例,男148例,女45例;年龄28～63岁,平均43.5岁;门静脉内径≤1.4cm者为乙组,共265例,男202例,女63例,年龄23～65岁,平均40.8岁。 2 方法 HA及LN均采用放射免疫法测定,试剂由上海海军医学研究所医学生物技术中心提供。门静脉测量:采用西门子公司
Serum hyaluronic acid (HA) and laminin (LN) were associated with the occurrence of cirrhosis of hepatitis. To further understand the exact relationship between HA and LN and portal hypertension caused by cirrhosis after hepatitis, 458 cases of liver cirrhosis Varied patients were compared, the report is as follows. 1 Clinical data 458 cases of hepatitis cirrhosis patients hospital from January 1994 to December 1997 inpatients and outpatients, in line with the 1995 Beijing Conference revised “viral hepatitis prevention and treatment program” sub-type diagnostic criteria. All patients were divided into two groups, portal vein diameter> 1.4cm were Group A, a total of 193 cases, 148 males and 45 females; aged 28 to 63 years, mean 43.5 years; portal vein diameter ≤ 1.4cm were Group B, A total of 265 cases, 202 males and 63 females, aged 23 to 65 years, mean 40.8 years. 2 Methods Both HA and LN were determined by radioimmunoassay. The reagents were provided by the Medical Biotechnology Center of Shanghai Naval Medical Research Institute. Portal vein measurements: Siemens