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目的 回顾研究已绝经与未绝经子宫内膜癌的病理分型,组织分级和手术病理分期等.方法 分析1987年1月～1996年12月上海第一妇婴保健院收治的138例子宫内膜癌患者,其中已绝经者93例,未绝经者45例.所有的病人都进行了分段诊刮,134例经过手术治疗.标本均进行了病理诊断,并根据1988年FIGO标准进行分期,所得资料用X~2Fisher’s exact test分析.结果 已绝经组与未绝经组比较,早期患者(IaG_1)比例明显偏低,分别占6%与32%.(P<0.001).G_2、G_3和非内胰腺癌的发生率是高的,分别是71%和51%(P<0.05).Ⅰc、Ⅱ、Ⅲ、Ⅳ期所占的比例较大,分别是40%和30%(P<0.001).五年生存率:已绝经组为74.2%,未绝经组91.4%,两者比较有明显意义(P<0.05).结论 已绝经子宫内膜癌患者预后较未绝经者差与临床和病理特点有关.
Objective To retrospectively study the pathological types, histological grades, and surgical pathological stages of menopause and non-menopause endometrial cancer. Methods Analysis of 138 cases of endometriosis admitted to Shanghai First Maternal and Child Health Hospital from January 1987 to December 1996 Among the cancer patients, 93 were postmenopausal and 45 were without menopause. All the patients had undergone segmented curettage and 134 patients had undergone surgical treatment. All specimens were pathologically diagnosed and were staged according to the 1988 FIGO criteria. The data were analyzed by X~2 Fisher’s exact test. The results were compared between the menopause group and the non-menopause group. The proportion of early-stage patients (IaG_1) was significantly lower, accounting for 6% and 32%, respectively (P<0.001). G_2, G_3, and non-endo-pancreas The incidence of cancer was high (71% and 51%, respectively) (P<0.05). The proportions of Ic, II, III, and IV were larger (40% and 30%, respectively) (P<0.001). The annual survival rate was 74.2% in the postmenopausal group and 91.4% in the non-menopausal group. There was significant difference between the two groups (P<0.05). Conclusion The prognosis of menopausal women with endometrial cancer is worse than that of nonmenopausal women with clinical and pathological features.