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OBJECTIVE: To determine the risk factors for progressive ischemic stroke, and to prevent onset and make a prognosis of disease, the present study systemically evaluated 19 cohort studies and 10 case-controlled studies of progressive ischemic stroke. SEARCH STRATEGY: A computer-based, online, literature search of PubMed (1966/2007), China Biological Medicine Database (CBM-disc, 1979/2007) and CNKI (www.cnki.net, 1979/2007) was performed to screen for related studies. DATA SELECTION: Cohort or case-controlled studies that focused on risk factors of progressive ischemic stroke were selected for review. Two reviewers independently extracted data and as-sessed study quality according to Cochrane Collaboration guidelines. Statistical analysis was per-formed using RevMan software. MAIN OUTCOME MEASUREMENT: Risk factors for progressive ischemic stroke. RESULTS: Using the inclusion criteria, 29/781 studies published in English and Chinese were ini-tially reviewed, including 19 cohort studies and 10 case-control studies. Despite variations in de-termination of progressive ischemic stroke and the intervals between 2 evaluations, all studies de-scribed the diagnostic criteria for progressive ischemic stroke. Logistic analysis was employed in 20 of the studies. Meta-analysis of primary data in the related studies determined that the following factors that significantly correlated with progressive ischemic stroke: fever [risk ratio (RR) = 2.26, 95% confidence interval (CI): 1.20–4.26, P = 0.01; odds ratio (OR) = 2.85, 95% CI: 1.64–4.98, P < 0.01)]; diabetes (RR = 1.38, 95% CI: 1.18–1.61, P < 0.01; OR = 2.48, 95% CI: 1.93–3.19, P < 0.01); coronary heart disease (RR = 1.22, 95% CI: 1.08–1.38, P < 0.01); neuroimaging transformation (RR = 1.55, 95%CI: 1.34–1.80, P < 0.01; OR = 2.29, 95% CI: 1.47–3.58, P < 0.01); and hypergly-cemia (RR = 2.62, 95% CI: 1.86–3.68, P < 0.01; OR = 3.49, 95% CI: 1.92–6.35, P < 0.01). CONCLUSION: Fever, diabetes, coronary heart disease, neuroimaging transformation, and hyper-glycemia are important risk factors for progressive ischemic stroke. Interventions for these risk fac-tors could effectively prevent occurrence of progressive ischemic stroke.
OBJECTIVE: To determine the risk factors for progressive ischemic stroke, and to prevent onset and make a prognosis of disease, the present study systemically evaluated 19 cohort studies and 10 case-controlled studies of progressive ischemic stroke. SEARCH STRATEGY: A computer-based, online, literature search of PubMed (1966/2007), China Biological Medicine Database (CBM-disc, 1979/2007) and CNKI (www.cnki.net, 1979/2007) was performed to screen for related studies. DATA SELECTION: Cohort Two case studies independently extracted data and as-sessed study according to Cochrane Collaboration guidelines. Statistical analysis was per-formed using RevMan software. MAIN OUTCOME MEASUREMENT: Risk factors for progressive ischemic stroke. RESULTS: Using the inclusion criteria, 29/781 studies published in English and Chinese were ini-tially reviewed, including 19 cohort studies an d 10 case-control studies. Despite variations in de-termination of progressive ischemic stroke and the intervals between 2 evaluations, all studies de-scribed the diagnostic criteria for progressive ischemic stroke. Logistic analysis was employed in 20 of the studies. Meta-analysis of primary data in the related studies determined that the following factors that significant correlated with progressive ischemic stroke: fever [risk ratio (RR) = 2.26, 95% confidence interval (CI): 1.20-4.26, P = ) = 2.85, 95% CI: 1.64-4.98, P <0.01); diabetes (RR = 1.38, 95% CI: 1.18-1.61, P <0.01; OR = 2.48, 95% CI: 0.01); coronary heart disease (RR = 1.22, 95% CI: 1.08-1.38, P <0.01); neuroimaging transformation (RR = 1.55, 95% CI: 1.34-1.80, P <0.01; OR = 2.29, 95% CI : 1.47-3.58, P <0.01); and hyperglycemia (RR = 2.62, 95% CI: 1.86-3.68, P <0.01; OR = 3.49, 95% CI: 1.92-6.35, P <0.01) CONCLUSION: Fever, diabetes, coronary heart disease, ne uroimaging transformation, and hyper-glycemia are important risk factors for progressive ischemic stroke. Interventions for these risk fac-tors could have prevented occurrence of progressive ischemic stroke.