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应用图像分析方法对118例胃粘膜异型增生活检组织石蜡切片标本细胞核仁组成区嗜银蛋白(AgNOR)颗粒数量与大小及细胞核平均面积、周长、体积进行了定量分析,并对44例进行了6～72个月(平均24个月)随访研究.结果显示,癌变组20例,其AgNOR平均颗粒效为8.35±2.42个/核,大颗粒效为1.05±0.52个/核;未癌变组24例,其平均颗粒数为5.51±1.43个/核,大颗粒数为0.42±0.22个/核,两组差异均有非常显著意义(P<0.01).此外,癌变组细胞核平均面积、周长、体积均较未癌变组增加(P<0.05或0.01).这表明AgNOR颗粒增多、增大和细胞核平均面积、周长、体积增加的异型增生与胃癌关系密切,对这些病人密切随访有助于胃癌的早期发现.
The image analysis method was used to quantitatively analyze the number and size of AgNOR particles in the nucleolus and the average area, perimeter and volume of nucleus in 118 paraffin-embedded paraffin-embedded specimens. Follow-up study for 6 to 72 months (average 24 months). The results showed that in the cancerous group, the mean particle efficiency of AgNOR was 8.35±2.42/nucleus, and the large particle effect was 1.05±0.52/nucleus; In the example, the average number of particles was 5.51±1.43/nucleus and the number of large particles was 0.42±0.22/nucleus. There was a significant difference between the two groups (P<0.01). In addition, the mean cell area and perimeter of the cancerous group were The volume increased compared with the non-cancerous group (P<0.05 or 0.01). This indicates that AgNOR granules increased, increased and the average area, circumference, and volume of dysplasia increased in close relationship with gastric cancer. Close follow-up of these patients is helpful for gastric cancer. Early detection.