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目的:研究透射电镜下线粒体功能评分及Gleason评分在预测前列腺癌进展中的价值。方法:2006年10月至2007年3月,选择前列腺癌根治术患者20例,年龄58～79(70.1±1.2)岁,在透射电镜下对前列腺癌上皮的线粒体功能进行评分,评分标准参照Flameng分级;同时分析上述患者的Gleason评分值,Gleason评分2～4分为Ⅰ组,5～7分为Ⅱ组。结果:Ⅰ组的线粒体功能评分为(4.0±0.8)分,Ⅱ组为(2.3±0.6)分,两组比较差异有显著性(P<0.05)。线粒体功能评分值与Gleason值呈负相关(r=-0.793,P<0.05);随访1年,低Gleason评分组(Ⅰ组)死亡率为0(0/8),高Gleason评分组(Ⅱ组)死亡率为50%(6/12),两者差异有显著性(P<0.05)。结论:前列腺癌患者中普遍存在线粒体功能紊乱,在恶性程度较高的患者更为严重。线粒体功能评分协同Gleason评分在预测前列腺癌进展中具有较大的价值。
Objective: To investigate the value of mitochondrial function score and Gleason score in predicting the progress of prostate cancer under transmission electron microscope. Methods: From October 2006 to March 2007, 20 patients with radical prostatectomy were selected, ranging in age from 58 to 79 (70.1 ± 1.2) years. The mitochondrial function of prostate cancer epithelium was evaluated by transmission electron microscopy. The Gleason scores of the above patients were also analyzed. The Gleason scores ranged from 2 to 4 in group Ⅰ and 5 to 7 in group Ⅱ. Results: The mitochondrial function score was (4.0 ± 0.8) in group Ⅰ and (2.3 ± 0.6) in group Ⅱ, the difference was significant (P <0.05). Mitochondrial function score was negatively correlated with Gleason value (r = -0.793, P <0.05). After a follow-up of 1 year, the mortality in low Gleason score group (0) was 0 (0/8) ) Mortality was 50% (6/12), the difference was significant (P <0.05). CONCLUSIONS: Mitochondrial dysfunction is prevalent in patients with prostate cancer and is more severe in more advanced malignancies. Mitochondrial function score synergy with Gleason score in predicting the progress of prostate cancer has great value.