论文部分内容阅读
现已公认,幽门螺杆菌(Helicobacter Pylori,HP)感染是引起消化性溃疡、慢性胃炎、胃粘膜相关淋巴组织淋巴瘤以及胃癌的重要原因。人群中Hp感染率很高,并且感染可持续数十年甚至终身,但大多数感染者为无症状携带者,小部分发生消化性溃疡,很少一部分发展为胃癌。宿主对HP免疫反应的差异可能是其中原因之一,Hp菌株的不同可能也是重要的一方面。近年发现有cagA基因的HP菌株具有更高的毒力,与胃、十二指肠疾病的关系更密切。
It is recognized that Helicobacter Pylori (HP) infection is an important cause of peptic ulcer, chronic gastritis, gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer. Hp infection rate in the population is high, and the infection can last for decades or even life, but most of the infected asymptomatic carriers, a small part of the occurrence of peptic ulcer, a small part of the development of gastric cancer. Differences in host immune response to HP may be one of the reasons, and differences in H. pylori strains may also be important aspects. In recent years, cagA gene was found in HP strains with higher virulence, and gastric, duodenal diseases more closely.