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长期低浓度的大气污染常可引起人类一系列呼吸道疾患,如大气中的悬浮颗粒物可引起肺部炎症及轻度纤维化的损害。悬浮颗粒物是城市大气中主要污染物之一,在制订大气悬浮颗粒物卫生标准中探讨肺部敏感的生物学指标显得十分重要。近年来,医学科学各分支对前列腺素(prostlaglandin,PG)研究得较深入。目前认为肺是PG合成、释放及代谢的主要器官之一。本文主要综述PG在肺部炎症、肺纤维化形成中病理及生化方面的作用,探讨制订大气污染物
Long-term low concentrations of air pollution can often cause a series of respiratory diseases in humans, such as airborne particulate matter can cause lung inflammation and mild fibrosis damage. Suspended particulate matter is one of the major pollutants in urban atmosphere. It is very important to explore the sensitive biological indicators of lung in the development of hygienic standards of atmospheric suspended particulate matter. In recent years, various branches of medical science have studied prostacylin (PG) more deeply. Now that the lung is PG synthesis, release and metabolism of one of the main organs. This article reviews the role of PG in the pathophysiology and biochemistry of pulmonary inflammation and pulmonary fibrosis,