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目的探讨子宫内膜血流阻力指数(resistance index,RI)及血清糖链抗原125(carbohydrate antigen 125,CA125)在子宫内膜癌诊断中的价值。方法子宫内膜癌患者52例,行彩色多普勒超声检查测定血流RI值,采用放射免疫法检测血清CA125水平,分析RI值、血清CA125水平与临床病理特征的关系。结果 52例患者RI阳性率为80.77%,血清CA125阳性率为76.92%;RI值随临床分级和病理分级增加、肌层浸润程度加深、宫腔最大径线增大及盆腔淋巴转移而降低(P<0.05);血清CA125水平随临床分级、病理分级增加、宫腔最大径线增大、盆腔淋巴结转移而增高(P<0.05),在肌层浸润程度上差异无统计学意义(P>0.05)。结论子宫内膜癌患者子宫内膜血流RI值和血清CA125水平与临床分级、病理分级等存在一定相关性。
Objective To investigate the value of endometrial blood flow resistance index (RI) and carbohydrate antigen 125 (CA125) in the diagnosis of endometrial carcinoma. Methods Fifty-two patients with endometrial carcinoma underwent color Doppler ultrasonography to measure the RI value of blood flow. The level of serum CA125 was detected by radioimmunoassay. The relationship between RI and serum CA125 level and clinicopathological features was analyzed. Results The positive rate of RI was 80.77% and the positive rate of serum CA125 was 76.92% in 52 patients. The RI value decreased with the increase of clinical grade and pathological grade, the deepening of myometrial invasion, the increase of the largest diameter of uterine cavity and the lymph node metastasis (P (P <0.05). There was no significant difference in the degree of myometrial infiltration between the level of serum CA125 and the pathological grade (P> 0.05) . Conclusion The endometrial blood flow RI value and serum CA125 level in patients with endometrial cancer have some correlation with clinical grade and pathological grade.