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General aspects:Currently,several strategies have been used to overcome common problems found in pharmacological therapies,such as insolubility,reduced bioavailability and low specificity of drugs.One of the most promising alternatives proposed is the use of dendrimeric drug nanocarriers,polymeric chemical structures of diverse nature that contain,transport and deliver the desired drug in biological systems.One of the dendrimers that has been most successfully used is based on polyamidoamine(PAMAM).PAMAM are organized from a central molecule of ethylenediamine that gives way to expansive growing layers(generations)terminating in a surface of primary amines that are positively charged at physiological p H.This architecture determines the presence of intramolecular cavities
General aspects: Currently, several strategies have been used to overcome common problems found in pharmacological therapies, such as insolubility, reduced bioavailability and low specificity of drugs. One of the most promising alternatives proposed is the use of dendrimeric drug nanocarriers, polymeric chemical structures of diverse nature that contain, transport and deliver the desired drug in biological systems. One of the dendrimers that has been most successfully used is based on polyamidoamine (PAMAM) .PAMAM are organized from a central molecule of ethylenediamine that gives way to expansive growing layers ( generations) terminating in a surface of primary amines that are positively charged at physiological p H.This architecture determines the presence of intramolecular cavities