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近日,著名国际期刊Nature Medicine发表了美国科学家的一项最新研究成果,他们发现特异性激活肠道FXR会促进肠道FGF15表达改变胆汁酸组成成分,同时能够通过增加产热以及白色脂肪棕色化,改善肥胖小鼠的体重及代谢恶化表型。研究人员指出,目前利用胆汁酸感应因子FXR的全身性表达靶向胆固醇代谢,甘油三酯合成,肝脏脂肪变性和胆汁淤积治疗相关疾病正成为新兴疗法。相比于全身性治疗方法,在进食情况下选择性释放胆汁酸能够激活肠道FXR。通过模拟这种组织特异性效应,利用特异性FXR激动
Recently, a well-known international journal Nature Medicine published a new study by American scientists. They found that specific activation of intestinal FXR can promote the expression of intestinal FGF15 to change the composition of bile acids. At the same time, by increasing the production of heat and white fat browning, Improves weight and metabolism of obese mice. The researchers point out that the current systemic use of bile acid sensing factor FXR targeting emerging cholesterol metabolism, triglyceride synthesis, liver steatosis and cholestasis-related diseases is emerging as a new therapy. Selective release of bile acids in the gut stimulates intestinal FXR as compared to systemic therapies. By simulating this tissue-specific effect, specific FXR agonism is utilized