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在寻找抗肿瘤抗菌素的过程中,从我国广州市土壤分离出一株对E. coli K-12(λ)有较强诱导活力的放线菌菌株72-2583,其代谢产物对肉瘤-180动物实验瘤株具有中等程度抑制率。 72-2583菌株与国外报道的链黑菌素(Streptonigrin)产生菌柔毛链霉菌(Streptomyces flocculus)极为近似,定名为柔毛链霉菌2583。其代谢产物链褐霉素的理化性质与文献报道的链黑菌素基本一致。经动物实验肿瘤试验证明,对小鼠U-14、B-22等瘤株有较明显的抑制率,
In the process of looking for anti-cancer antibiotics, an actinomycete strain 72-2583 with stronger induced activity to E. coli K-12 (λ) was isolated from the soil of Guangzhou city of China. The metabolites of the strain act on sarcoma-180 animals The experimental tumor strains have a moderate inhibition rate. The 72-2583 strain closely resembles the Streptomyces flocculus, a Streptomyces-producing strain of Streptomyces, which is reported abroad. The physicochemical properties of its metabolite of streptomycin and reported in the literature of the same chain of streptozotocin. Tumor experiments in animal experiments proved that mice U-14, B-22 and other tumor strains have a more significant inhibition rate,