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基质金属蛋白酶(matrix metalloproteinases,MMPs)是一组依赖锌离子,具有相同功能、结构高度同源的内肽酶的总称,主要功能是降解细胞外基质(extracellular matrix,ECM)和基底膜。基质金属蛋白酶抑制剂(tissue inhibitors of metalloprotein-ases,TIMPs)为MMPs的天然抑制剂,能特
Matrix metalloproteinases (MMPs) are a group of zinc-dependent endopeptidases that have the same functions and are highly homologous to their structures. Their main function is to degrade the extracellular matrix (ECM) and the basement membrane. Tissue inhibitors of metalloprotein-ases (TIMPs) are natural inhibitors of MMPs,