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采用示踪动力学方法测定了正常大鼠和给丙磺舒、血管紧张素Ⅱ及地塞米松大鼠的血浆代谢清除率和产生速率(见表)。结果表明:丙磺舒明显降低了血浆cAMP的浓度和产生速率。说明该药不仅使血中cAMP的清除受到阻滞,而且抑制了细胞内cAMP向外周血的释放。丙磺舒在神经介质代谢研究中和在临床上是一种广泛应用的代谢阻断剂,了解其对cAMP生成和代谢的影响,可为正确使用该药提供依据,同时也进一步阐明了其药理作用。血管紧张素Ⅱ显著地增加了血浆cAMP浓度和产生速率,但代谢清除率不变。这可以解释肾素血管紧张
Tracer kinetics were used to determine plasma metabolic clearance and rate of release of probenecid, angiotensin II, and dexamethasone in normal rats and in rats (see table). The results showed that probenecid significantly reduced plasma cAMP concentration and production rate. This drug not only blocked the clearance of cAMP in blood, but also inhibited the release of intracellular cAMP to peripheral blood. Probenecid is widely used as a metabolic blocker in the study of neurotransmitter metabolism and its influence on the production and metabolism of cAMP, which can provide the basis for the correct use of this drug. It also further clarifies its pharmacological effect. Angiotensin II significantly increased plasma cAMP concentration and rate of production, but metabolic clearance did not change. This can explain renin vascular tension