菟丝子多糖H3的研究

• 作 者: 王展 刘翠平 方积年
• 机 构: 中国科学院上海生命科学研究院上海药物研究所,上海,200031
• 出 处: 中国药学(英文版)
• 发表日期: 2001年2期
• 关键词: Cuscuta chinensis Convolvulaceae Polysaccharides NMR Methylation analysis Partia

首次从中药菟丝子(Cuscuta chinedsis Lam.)中得到一均一酸性多糖H3,并采用化学及光谱方法对其结构特征进行了研究.结果表明该多糖为一多分枝的复杂多糖,由1,6-linked-β-D Galp,1,4-linked-β-D Galp,1,4-linked-β-D GalA,1,3,6-linked-β-D Galp及1,2,4-linked Rhap组成,分枝点位于1,2,4-linked Rhap的O-2或O-4以及1,3,6-linked-β-D Galp的O-3位,并以1-linked Galp为末端.侧链由1-linked Araf,1,5-linked Araf和1,3,5-linked Araf构成,并连接于主链的1,6-linkedGalp的O-3位.“,”H3, a homogeneous acidic polysaccharide was obtained from the seeds of Cuscuta chinensis Lam. Its structure was characterized for the first time by chemical and spectroscopic methods to be a highly branched heteropolysaccharide with mean molecular weight of more than 1×106. It was composed of 1,6-linked-β-D Galp, 1,4-linked-β-D Galp, 1,4-linked-β-D GalA, 1,3,6-linked-β-D Galp and 1,2,4-linked Rhap, with branching points at O-2or O-4 of 1,2,4-linked Rhap and O-3 of 1,3,6-linked-β-D Galp. Its side chains included 1-linked Araf, 1,5-linked Araf and 1,3,5-linked Araf at O-3 of 1,6-linked Galp in the main chain.