去氧孕烯/孕二烯酮避孕药有致静脉血栓栓塞危险

• 作 者: 孙黎敏
• 出 处: 药物不良反应杂志
• 发表日期: 2003年01期
• 关键词: 去氧孕烯 静脉血栓栓塞 孕二烯酮 左炔诺孕酮 药品专利 EMEA 第三代 产后期 静脉血栓形成 外科手术

EMEA药品专利委员会(CPMP)依据1995年～2001年9月的资料,公布了关于所谓“第三代”复方口服避孕药(COC,含孕激素去氧孕烯desogestrel或孕二烯酮gestodene)与诱发静脉血栓栓塞(VTE)危险性关联的评价结果,结论如下:服用含去氧孕烯或孕二烯酮的口服避孕药(与含左炔诺孕酮的避孕药比较,相对危险度是1.5～2.0)出现VTE的危险性有所增加,特别是在开始服用复方口服避

According to the information from 1995 to September 2001, the EMEA Pharmaceutical Patents Committee (CPMP) published a report on the so-called “third generation” of oral contraceptives (COC, desogestrel containing gestodene or gestodene) The results of the evaluation associated with the risk of developing venous thromboembolism (VTE) were as follows: Oral contraceptives containing either desogestrel or gestodene (relative risk for contraceptives containing levonorgestrel 1.5 ~ 2.0) increased the risk of VTE, especially in the beginning to take oral compound to avoid