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用生物学方法检测２８例慢活肝患者ＰＢＭＣ的ＩＬ－２水平，用葡萄球菌免疫球蛋白间接花环法检测其ＩＬ－２Ｒ表达细胞（ＩＬ－２Ｒ＋，ｍＩＬ－２Ｒ）的百分率，用ＥＬＩＳＡ法测定ｓＩＬ－２Ｒ。结果显示慢活肝患者在ＩＬ－２与ＩＬ－２Ｒ＋明显下降的同时，其ｓＩＬ－２Ｒ较正常对照值明显增高（ｓＩＬ－２Ｒ分别为３１４．６±１０６．７５ｋＵ／Ｌ与６５±３１．５０ｋＵ／Ｌ，Ｐ＜０．０５）；ｓＩＬ－２Ｒ的增高与ＩＬ－２下降，与ＩＬ－２Ｒ＋表达减少呈负相关（ｎ＝２４，分别ｒ＝－０．７６３，Ｐ＜０．００１；ｒ＝－０．８８４，Ｐ＜０．００１）。ＡＬＴ正常后６个月复查ＩＬ－２回升，ＩＬ－２Ｒ＋及ｓＩＬ－２Ｒ趋向正常。本义重点讨论了ｓＩＬ－２Ｒ增高的意义。
IL-2 levels in peripheral blood mononuclear cells of 28 patients with chronic liver disease were detected by biological methods. The percentage of IL-2R-expressing cells (IL-2R +, mIL-2R) was detected by indirect immunocytochemistry with staphylococcus aureus, sIL-2R. The results showed that IL-2 and IL-2R in IL-2 and IL-2R significantly decreased in patients with chronic liver disease, while the sIL-2R levels were significantly higher than the normal controls (sIL-2R were 314.6 ± 106.75kU / L and 65 ± 31.50kU /L,P<0.05); The increase of sIL-2R was associated with the decrease of IL-2, and was negatively correlated with the decrease of IL-2R + expression (n = 24, r = -0.763, = -0.884, P <0.001). After 6 months of normal ALT IL-2 recovery, IL-2R + and sIL-2R tended to be normal. The original meaning focuses on the significance of increased sIL-2R.