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脆性组氨酸三联体(FHIT)基因是Ohta等〔1〕于1996年在3p14.2上找到的一种新的抑癌基因,在肺癌发生中起重要作用,在吸烟者中这种作用更加明显,其低表达可促进肺癌的发生和发展,影响某些化疗药物敏感性,并具有预后评估价值。FHIT基因包括t(3;8)断裂点、FRA3B及HPV16整合位点,在染色体上占据了约2Mb的位置。FHIT基因共有含有10个外显子,其中第5~9外显子(约1.1kb)编码146个氨
The FHIT gene is a novel tumor suppressor gene found by Ohta et al. [1] at 3p14.2 in 1996 and plays an important role in the development of lung cancer. This effect is more pronounced in smokers Obviously, its low expression can promote the occurrence and development of lung cancer, affect the sensitivity of some chemotherapeutic drugs, and have a prognostic value. The FHIT gene includes the t (3; 8) breakpoint, FRA3B and HPV16 integration sites, occupying approximately 2 Mb on the chromosome. FHIT gene contains a total of 10 exons, of which 5 to 9 exons (about 1.1kb) encoding 146 ammonia