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目的:探讨骨桥蛋白(OPN)与CD44v6在胆管癌组织中的表达及其临床意义。方法:采用免疫组化Elivision法检测OPN与CD44v6在46例胆管癌、癌旁胆管组织中的表达情况,并对临床病理特征进行对比分析。结果:OPN与CD44v6在胆管癌组织中的表达均明显高于癌旁胆管组织,并且与患者肿瘤分期、有无淋巴结转移相关(P<0.05),与年龄、性别、肿瘤分化程度无相关性(P>0.05);通过Spearman等级相关分析,胆管癌中OPN表达与CD44v6的表达呈正相关(r=0.326,P=0.027)。结论:OPN与CD44v6在胆管癌组织中表达明显增高,与肿瘤分期、淋巴结转移相关,是胆管癌重要的生物学指标。在胆管癌组织中OPN与CD44v6的表达呈正相关,两者联合检测对于胆管癌诊断、鉴别诊断及预后判断具有重要意义。
Objective: To investigate the expression of osteopontin (OPN) and CD44v6 in cholangiocarcinoma and its clinical significance. Methods: The expressions of OPN and CD44v6 in 46 cases of cholangiocarcinoma and adjacent bile duct tissue were detected by immunohistochemical Elivision method, and the clinicopathological characteristics were compared. Results: The expressions of OPN and CD44v6 in cholangiocarcinoma tissues were significantly higher than those in adjacent tissues (P <0.05), but not with age, sex and tumor differentiation P> 0.05). According to Spearman rank correlation analysis, there was a positive correlation between OPN expression and CD44v6 expression in cholangiocarcinoma (r = 0.326, P = 0.027). Conclusion: The expression of OPN and CD44v6 in cholangiocarcinoma tissues is significantly increased, which is correlated with tumor stage and lymph node metastasis. It is an important biological indicator of cholangiocarcinoma. The expression of OPN and CD44v6 in cholangiocarcinoma was positively correlated, and the combined detection of them was of great significance for the diagnosis, differential diagnosis and prognosis of cholangiocarcinoma.