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目的:探讨脑蛋白水解物注射液对老年帕金森患者的疗效及安全性。方法:选取120例老年帕金森患者,按随机数字表法分为两组,对照组(57例)给予常规治疗,观察组(63例)在常规治疗基础之上静脉滴注脑蛋白水解物注射液,观察并记录两组统一帕金森评分量表(UPDRS)评分、SF-36量表评分及治疗期间不良反应的发生情况。结果:治疗前,两组UPDRS评分、SF-36量表各项评分相比均无统计学差异(P>0.05);治疗后,两组UPDRS各项评分及总分均较治疗前明显降低,且观察组UPDRS各项评分及总分较对照组低(P<0.05),社会功能、情感职能、精神健康评分明显高于对照组(P<0.05)。治疗期间,对照组发生1例头晕,1例恶心,不良反应率为3.5%;观察组发生2例失眠,1例乏力,1例眩晕,1例恶心,不良反应率为7.9%。两组不良发应率相比差异无统计学意义(P>0.05)。结论:脑蛋白水解物注射液对老年帕金森具有较好的疗效,能够提高患者思维能力,改善精神健康,提高其生活质量,且安全性较高。
Objective: To investigate the efficacy and safety of brain protein hydrolyzate injection in elderly patients with Parkinson’s disease. Methods: One hundred and twenty elderly patients with parkinsonism were divided into two groups according to the random number table. The control group (n = 57) received routine treatment. The observation group (n = 63) received routine intravenous infusion of brain protein hydrolyzate The UPDRS scores, SF-36 scale scores and adverse reactions during treatment were observed and recorded. Results: Before treatment, there was no significant difference between UPDRS scores and SF-36 scores in both groups (P> 0.05). After treatment, the score and total score of UPDRS in both groups were significantly lower than those before treatment, The UPDRS score and total scores in the observation group were lower than those in the control group (P <0.05). Social function, emotional function and mental health score were significantly higher in the observation group than those in the control group (P <0.05). During the treatment period, one case of dizziness and one case of nausea occurred in the control group, with a rate of 3.5%. Two cases of insomnia, one case of fatigue, one case of dizziness and one case of nausea were observed in the observation group. The rate of adverse reactions was 7.9%. There was no significant difference in adverse reaction rate between the two groups (P> 0.05). CONCLUSIONS: Brain protein hydrolyzate injection has a good effect on Parkinson’s disease in elderly patients. It can improve patients’ thinking ability, improve mental health, improve their quality of life, and have higher safety.