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桃儿七根及根茎的乙醇提取物对体外培养的人红白血病K_(562)细胞、小鼠白血病L_(1210)细胞及L_(7712)细胞,用小孔板法,10.0、5.0、2.5及1.0μg/ml终浓度剂量,24h后残留率分别为44.17％、47.63％、64.43％、79.57％,42.84％、50.73％、63.21％、75.10％及39.76％、46.36％、61.42％、75.24％;该药品小鼠单次腹腔注射LD_(50)为76.3～60.6mg/kg;对小鼠移植性肿瘤EAC、U_(14)及H_C,该药品用14.0mg/kg及7.0mg/kg剂量,瘤重抑制率分别为42.2％、37.8％,38.8％、33.3％及41.5％、35.6％。
Ethanol extracts from seven rhizomes and rhizomes of P. edodes on human erythroleukemia K 562 cells, mouse leukemia L 1210 cells and L 7712 cells cultured in vitro using small well plate method, 10.0, 5.0, 2.5 and At the final concentration of 1.0μg/ml, the residual rates after 24h were 44.17%, 47.63%, 64.43%, 79.57%, 42.84%, 50.73%, 63.21%, 75.10% and 39.76%, 46.36%, 61.42%, and 75.24%, respectively. The single-dose intraperitoneal injection of LD_(50) was 76.3～60.6mg/kg. The mice were transplanted with tumors EAC, U_(14) and H_C. The drug was administered with 14.0mg/kg and 7.0mg/kg tumors. The heavy inhibition rates were 42.2%, 37.8%, 38.8%, 33.3%, 41.5%, and 35.6%, respectively.