甲巯咪唑引起肝损害

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患者女,42岁。因甲状腺功能亢进、结节性甲状腺肿,服用甲巯咪唑10mg,3次/d,利血生、普萘洛尔治疗1月。出现乏力、食欲不振、尿黄、皮肤重度黄疸,实验室检查显示:ALT1670U/L,AST1524.3U/L,TBil289.3μmol/L,DBil129.3μmol/L,ALB28.9g/L,A/G0.7,B超提示:肝回声偏粗。停用甲巯咪唑,其他药继续使用,并给予保肝治疗。1月后,患者症状逐渐好转,肝功能恢复正常。 Female patient, 42 years old. Due to hyperthyroidism, nodular goiter, taking methimazole 10mg, 3 times / d, reserpine, propranolol treatment in January. There was fatigue, loss of appetite, urine yellow, severe skin jaundice. Laboratory tests showed ALT1670U / L, AST1524.3U / L, TBil289.3μmol / L, DBil129.3μmol / L, ALB28.9g / L and A / G0. 7, B-Tip: partial thick echo of the liver. Stop methimazole, other drugs continue to use, and give liver protection. After 1 month, the patient’s symptoms gradually improved, liver function returned to normal.
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