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近年来,化脓性脑膜炎对氯霉素和氨苄青霉素耐药菌株增多,故作者将220例3个月～15岁的化脓性脑膜炎儿童患者,随机应用氯霉素(Ch)、氨苄青霉素(AP)、头孢氨噻肟(CTX)和头孢三嗪噻肟(CTA)治疗,并比较其疗效。病人和方法化脓性脑膜炎的诊断依靠①CSF 培养阳性;②有临床症状和体征,CSF 白细胞数≥100个/mm~3;③下列中的一项或一项以上:血培养阳性,CSF 用格兰染色找到细菌;阳性的血清学试验。病原学分布如下:嗜血流感杆菌 B(Hib)146例,脑膜炎双球菌(Mnc)32例,肺炎球菌(Pnc)13例,其他细菌及不明原因者9例。药物剂量如下,Ch100mg/kg/d,Ap250mg/kg/d,CTX150mg/kg/d,CTA100mg/kg/d,各药均由静脉给药,前三者每天剂量
In recent years, suppurative meningitis on chloramphenicol and ampicillin resistant strains increased, so the author of 220 cases of 3 months to 15 years of purulent meningitis in children with chloramphenicol (Ch), ampicillin ( AP), cefotaxime (CTX) and ceftriaxone treatment (CTA), and to compare their efficacy. Patients and methods The diagnosis of purulent meningitis relies on ①CSF culture positive; ② clinical symptoms and signs, CSF white blood cell count ≥100 / mm ~ 3; ③ one or more of the following: blood culture positive, CSF with grid Blue stain to find bacteria; positive serological test. The etiological distribution was as follows: 146 cases of Hib (Hib), 32 cases of Neisseria meningitidis (Mnc), 13 cases of Pneumococcus (Pnc), 9 cases of other bacteria and unexplained causes. The doses of the drugs were as follows: Ch100mg / kg / d, Ap250mg / kg / d, CTX150mg / kg / d and CTA100mg / kg / d.