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目的探讨广东地区大肠癌临床特点和变化趋势。方法总结分析广东五家医院1990年至2004年经病理确诊的大肠癌6501例资料。结果6501例大肠癌患者中位年龄59岁,好发年龄为61～70岁。青年大肠癌的比例从7.1%下降到3.5%。男:女为1.47:1,男性多于女性;随年龄增长。男女比例逐渐上升。于60岁左右达高峰后下降.呈一单峰曲线。在直肠癌与结肠癌比例为1.1:1,其中降结肠以上占27.6%,但随年龄增长和年份推移,直肠癌逐渐减少.而右半结肠癌逐渐增加。组织学分型以管状腺癌为主,占76.0%。住院患者Dukes分期多为中晚期.进展期癌(Dukes B、C、D期)共占93.9%。结论广东地区大肠癌发病高峰年龄已接近西方国家;青年大肠癌比例下降;男女比例随年龄增长呈先升后降趋势;直肠癌比例逐渐减少,右半结肠癌比例逐渐增加.发病部位右移提示应重视全结肠镜检查。
Objective To investigate the clinical features and trends of colorectal cancer in Guangdong. Methods The data of 6501 cases of colorectal cancer confirmed by pathology from 1990 to 2004 in five hospitals in Guangdong Province were summarized and analyzed. Results The median age of 6501 cases of colorectal cancer was 59 years and the incidence was 61 ~ 70 years old. The proportion of young people with colorectal cancer dropped from 7.1% to 3.5%. Male: Female 1.47: 1, more men than women; with age. The male-female ratio is gradually rising. After reaching the peak of about 60 years old, it drops, showing a single peak curve. The ratio of rectal cancer to colon cancer was 1.1: 1, of which 27.6% was lower than that of the descending colon, but with age and years, the number of rectal cancer decreased gradually while the number of right colon cancer increased gradually. Histological type tubular adenocarcinoma, accounting for 76.0%. Dukes staging of hospitalized patients were mostly in the advanced stage, advanced stage cancer (Dukes B, C, D) accounted for 93.9%. Conclusions The age of onset of colorectal cancer in Guangdong is close to that in western countries. The proportion of young patients with colorectal cancer is declining. The proportion of male to female is increasing at first and then decreasing with the increase of age. The proportion of rectal cancer is decreasing and the percentage of right colon cancer is increasing. Should pay attention to the colonoscopy.