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口服锑钾肠溶片给药方便,适用于大规模的血吸虫病治疗。一般来说,血锑浓度的增高和口服锑钾肠溶片的剂量成正比,但若口服锑钾肠溶片的剂量过高,则情况就不同了,我们在1957年以口服锑钾肠溶片治疗家兔血吸虫病的实验中,发现锑钾肠溶片的剂量过高时,并不能使血锑浓度升高,在个别家兔的小肠有多数坏死灶形成。为了进一步观察锑钾对肠壁的损害,并和锑钾液灌胃相比较,特作本实验。实验方法家兔56只,分成三组:第一组及第二组为酒石酸锑钾肠溶片(上海科字院药物研究所药品制剂研
Antimony potassium oral administration of oral convenience, for large-scale treatment of schistosomiasis. In general, blood antimony concentration increases and the dose of oral antimony potassium enteric-coated tablets is proportional to, but if the oral antimony potassium enteric-coated tablets overdose, the situation is different, and we in 1957 oral antimony potassium enteric-coated In the experiment of treating schistosomiasis in rabbits, it was found that when the dose of antimony potassium enteric-coated tablets is too high, the blood antimony concentration can not be increased, and the necrosis of the small intestine of most rabbits is formed. In order to further observe the damage of antimony potassium on the intestinal wall, and compared with antimony potassium solution gavage, special for this experiment. Experimental methods 56 rabbits were divided into three groups: the first group and the second group of antimony potassium tartrate enteric-coated tablets (Shanghai Institute of Pharmaceutical Research Pharmaceutical Institute Institute