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造血生长因子极大的方便了外周血干细胞(PBSC)的动员和采集。但G-CSF和GM-CSF孰优孰劣尚无定论。本文首次用双盲法随机研究了二者动员PBSC的效果及移植后造血恢复的情况。 1992.8～1996.12共26例(男14,女12)难治性及复发的霍奇金病患者进入此组,中数年龄31岁。化疗方案:地塞米松24mg/天,1～7天;司莫司汀60mg/m~2,第2天;足叶乙甙75mg/天,4～7天(总量300mg/m~2);阿糖胞苷100mg/m~2,每日2次,4～7天(总量800mg/m~2)。化疗后第一天病人随机分为2组,分
Hematopoietic growth factors greatly facilitate the mobilization and collection of peripheral blood stem cells (PBSC). However, the G-CSF and GM-CSF are still inconclusive. This article was the first to use a double-blind method to investigate the effect of mobilization of PBSC and the recovery of hematopoietic after transplantation. From 1992.8 to 1996.12, a total of 26 patients (14 males and 12 females) with refractory and relapsed Hodgkin’s disease entered this group, with a median age of 31 years. Chemotherapy regimen: Dexamethasone 24 mg/day, 1 to 7 days; Semustine 60 mg/m~2, Day 2; Etoposide 75 mg/day, 4 to 7 days (total 300 mg/m~2) ; Cytarabine 100mg/m~2, twice daily, 4 to 7 days (total 800mg/m~2). Patients were randomly divided into two groups on the first day after chemotherapy.