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本文观察了20例男性Graves病患者抗甲状腺药物治疗前后的唾液睾酮及血清中几种性激素水平的变化,并与年龄、性别相配对的20例健康者进行了比较分析。患者治疗前唾液睾酮水平明显低于正常,治疗后显著上升,与血T_3、T_4的变化呈负相关;治疗前血总睾酮、雌二醇、LH及FSH显著高于正常,治疗2个月后除雌二醇外均随T_3、T_4的下降而下降。本文结果支持唾液睾酮不受SHBG的影响,提示Graves病患者游离睾酮减低。
In this paper, we observed the changes of salivary testosterone and serum sex hormones in 20 Graves’ patients before and after treatment with anti-thyroid drugs, and compared them with age and sex matched 20 healthy people. The level of salivary testosterone in patients before treatment was significantly lower than that in normal group, but increased significantly after treatment, which was negatively correlated with the changes of blood T 3 and T 4. The total testosterone, estradiol, LH and FSH were significantly higher than those before treatment In addition to estradiol outside with T_3, T_4 decline and decline. Our results support saliva testosterone is not affected by SHBG, suggesting that patients with Graves disease free testosterone decreased.