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目的 探讨白细胞介素 13(IL 13)在抑制脑卒中炎性损伤中的作用。方法 用酶联免疫吸附法 (ELISA)测定 5 0例脑梗死患者及 30例脑出血患者发病后 48h内及第 6～ 8天、第 15天血浆IL 13的水平 ,并检测 6 0例对照者的血浆IL 13水平。结果 脑梗死组 3个时相血浆IL 13水平 (ng/L)分别为 37 6± 6 2 ,45 2± 10 1,41 3± 8 3;脑出血组为 36 6± 4 9,45 3± 8 9,38 1± 5 6 ;均较危险因素对照组 (2 8 0± 3 2 )及健康对照组 (2 6 4± 2 7)明显增高。中度 (脑梗死组 :40 7± 5 8,5 1 1± 8 0 ,44 8± 7 2 ;脑出血组 :38 2± 4 1,48 2± 5 8,38 7± 4 1)及重度 (脑梗死组 :42 3± 5 2 ,5 3 3± 7 2 ,47 3± 9 6 ;脑出血组 :38 6± 3 9,5 2 2± 9 2 ,40 6± 7 6 )患者血浆IL 13水平明显增高 ,且第 6～ 8天的水平最高。结论 IL 13可能参与了抑制脑卒中炎性损伤的病理过程 ,并与病情程度呈正相关。
Objective To investigate the role of interleukin-13 (IL-13) in inhibiting inflammatory injury in stroke. Methods Plasma levels of IL-13 in 50 patients with cerebral infarction and 30 patients with cerebral hemorrhage were measured by enzyme-linked immunosorbent assay (ELISA) within 48 hours, 6th to 8th days and 15th days after onset, and 60 controls Of plasma IL-13 levels. Results The plasma levels of IL-13 in the three phases of cerebral infarction group were 37 6 ± 6 2 and 45 2 ± 10 1 and 41 3 ± 8 3, respectively. The levels of IL-13 in cerebral hemorrhage group were 36 6 ± 4 9 and 45 3 ± 8 9,38 1 ± 5 6, respectively, which were significantly higher than those in control group (28 0 ± 3 2) and healthy control group (26 4 ± 2 7). Moderate (cerebral infarction group: 40 7 ± 5 8, 51 1 ± 8 0, 44 8 ± 7 2; cerebral hemorrhage group: 38 2 ± 4 1, 48 2 ± 5 8, 38 7 ± 4 1) and severe (Cerebral infarction group: 42 3 ± 5 2, 5 3 3 ± 7 2, 47 3 ± 9 6; cerebral hemorrhage group: 38 6 ± 3 9,5 2 2 ± 9 2, 40 6 ± 7 6) 13 levels were significantly higher, and the highest level of 6 to 8 days. Conclusion IL-13 may be involved in the pathological process of inhibiting the inflammatory injury induced by stroke, which is positively correlated with the severity of the disease.