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目的比较不同的促排卵方法联合宫腔内人工授精(IUI)治疗不孕症的疗效。方法224对夫妇为观察对象行IUI治疗,共826个周期,分为4组:自然周期(NC)对照组共163个周期,克罗米酚(CC)组375个周期,克罗米酚联合人绝经期促性腺激素(CC-HMG)组152个周期,HMG组136个周期。结果自然周期对照组的周期妊娠率为11.4%;CC组、CC-HMG组、HMG组的周期妊娠率依次为12.8%、22.4%、23.5%,CC-HMG组的HMG用量显著小于HMG组(P<0.001)。结论CC-HMG和HMG促排卵联合IUI均能提高IUI治疗不孕症的妊娠率,CC-HMG促排卵药费支出少,更具有优势。
Objective To compare the efficacy of different ovulation induction methods combined with intrauterine insemination (IUI) in the treatment of infertility. Method 224 The couple were treated with IUI for a total of 826 cycles and divided into 4 groups: 163 cycles in the control group of natural cycles (NC), 375 cycles in the clomiphene phenol (CC) group, Human menopausal gonadotropin (CC-HMG) group of 152 cycles, HMG group of 136 cycles. Results The cycle pregnancy rate was 11.4% in the control group and 12.8%, 22.4% and 23.5% in the CC group, CC-HMG group and HMG group respectively. The HMG dosage in the CC-HMG group was significantly lower than that in the HMG group P <0.001). Conclusion Both CC-HMG and HMG combined with IUI can improve the pregnancy rate of infertility treated with IUI, and CC-HMG has less ovulation and ovulation costs, which is more advantageous.