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用放免法检测64例慢性肝病患者、20例正常人血清透明质酸（HA）及Ⅲ型前胶原（PCⅢ）。结果表明：慢性活动型肝炎、肝硬化病人血清HA及PCⅢ水平明显高于慢性迁延型肝炎及正常人，肝硬化病人血清HA及PCⅢ水平又显著高于慢性活动型肝炎病人，而慢性迁延型肝炎病人血清HA及PCⅢ水平与正常人相比无显著性差异。检测血清HA及PCⅢ对慢性肝病的诊断、预后判断及疗效观察均具重要临床意义，并且血清HA及KCⅢ联合检测优于HA或PCⅢ单项检测。
Totally 64 cases of chronic liver disease and 20 cases of normal human serum hyaluronic acid (HA) and type Ⅲ procollagen (PC Ⅲ) were detected by radioimmunoassay. The results showed that the levels of serum HA and PCⅢ in patients with chronic active hepatitis and cirrhosis were significantly higher than those in patients with chronic persistent hepatitis and normal. The levels of serum HA and PCⅢ in cirrhotic patients were significantly higher than those in patients with chronic active hepatitis, while patients with chronic persistent hepatitis Patients with serum HA and PC Ⅲ levels compared with normal people no significant difference. Detection of serum HA and PC Ⅲ in the diagnosis of chronic liver disease, prognosis and efficacy are important clinical significance, and combined detection of serum HA and KC Ⅲ is better than HA or PC Ⅲ single detection.