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亚胺培南/西司他了钠(Imipenem/cilastatin sodium,别名:泰能),是第一个用于临床的碳青霉烯类抗生素,为亚胺培南和西司他丁钠的复合物,二者的比例为1:1。它通过抑制细菌细胞壁的合成而杀灭革兰氏阳性菌、阴性菌及厌氧菌,抗菌谱广,临床用于治疗各种常见致病菌引起的各系统感染。近年来广泛用于临床,有效率均在85％以上。但也报道使用产生了一些不良反应,应引起医护人员的重视。 1 神经精神系统 1.1 肌肉抽搐张群等报道,男,92岁,入院后慢支急性发作,病情加重,用复达欣效不佳,后突然意识丧失、心率、呼吸、血压降至0。停用复达欣,改用泰能1.0g,静滴,1/12h。4天后多次出现腹部肌肉阵发性抽搐,对症处理效不明显,随后持续抽搐,经会诊考虑泰能
Imipenem / cilastatin sodium is the first carbapenem antibiotic to be used clinically, a combination of imipenem and cilastatin sodium The ratio of the two is 1: 1. It inhibits Gram-positive bacteria, negative bacteria and anaerobic bacteria by inhibiting the synthesis of bacterial cell wall, broad antibacterial spectrum, and is used clinically to treat various systemic infections caused by various common pathogenic bacteria. In recent years, widely used in clinical, the effective rate of more than 85%. However, some adverse reactions have also been reported in the course of use, which should be paid more attention by medical staff. 1 neuropsychiatric system 1.1 muscle convulsions Zhang Qun and other reports, male, 92 years old, admitted to hospital after an acute attack of chronic bronchitis, exacerbations, with complex up to Yan Xin ineffective, after a sudden loss of consciousness, heart rate, respiration, blood pressure dropped to zero. Disable the use of Yan, switch to Thailand to 1.0g, intravenous infusion, 1 / 12h. 4 days after repeated abdominal muscle paroxysmal convulsions, symptomatic treatment effect is not obvious, then continued convulsions, after consultation to consider Thai energy