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本文在养胃冲剂临床应用获得确切疗效的基础上,对其由甲硝基亚硝胍造模的慢性萎缩性胃炎大鼠进行有关实验观察,旨在探讨养胃冲剂的药物作用机理。结果表明冲剂组胃粘膜镜下观察其组织学改变较模型组明显减轻,与正常组肉眼差别不大;造模组大鼠胃粘膜PGE_2和SS水平显著降低,MOT水平显著升高,养胃冲剂可使慢性萎缩性胃炎大鼠胃粘膜PGE_2、SS明显升高(P<0.05～0.01),可使MOT有所降低,但无显著差异。由此说明养胃冲剂是通过调节胃肠道激素水平起到保护和修复胃粘膜作用。
In this paper, based on the clinical application of Yangwei granules to obtain the exact curative effect, the experimental observation of rats with chronic atrophic gastritis modeled by nitro-nitrosoguanidine was conducted to explore the mechanism of drug action of Yangwei granules. The results showed that the histological changes of the granule group were significantly less than those of the model group compared with the model group, and the difference was not significant between the granule group and the normal group. The level of PGE 2 and SS in the gastric mucosa of the model group was significantly decreased, and the MOT level was significantly increased. The gastric mucosal PGE 2 and SS in rats with chronic atrophic gastritis were significantly increased (P<0.05-0.01), and the MOT was decreased, but there was no significant difference. This shows that Yangwei granules protect and repair gastric mucosa by regulating gastrointestinal hormone levels.