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Ｂ群脑膜炎球菌为大多数温带国家的主要致病菌，英国２／３以上的培养确诊的病例由Ｂ群菌株引起，因此研制安全有效的Ｂ群脑膜炎球菌菌苗具有重大的公共卫生价值。作者采用基因工程的方法构建了两个各表达３种１类外膜蛋白（ＰｏｒＡOＭＰ）的Ｂ群菌苗株。将从这两个菌苗株中纯
Meningococcal meningitis group B is the major causative agent in most temperate countries. More than two-thirds of all confirmed cases of infection in the United Kingdom are caused by serogroup B strains. Therefore, developing a safe and effective meningococcal group B vaccine has significant public health value . The authors used genetic engineering methods to construct two groups of B strain that express three types of outer membrane proteins (PorAOMP). It will be pure from both strains