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目的探索伽玛刀治疗原发性癫的细胞学机理。方法建立大鼠皮质青霉素局灶性癫癎模型,将SD大鼠随机分为实验组、实验对照组和对照组。照射周边剂量12 Gy, 等剂量曲线为50%。分别于0.5 h~2个月后取靶区皮质及海马标本制备光镜、常规透射电镜样品。结果癫癎模型鼠可见较多凋亡神经元,而癫癎模型鼠经低剂量伽玛刀照射后同时程的神经元改变较轻微,凋亡细胞少见。结论凋亡参与了青霉素致癫癎发作后海马神经元的死亡过程,低剂量伽玛刀照射对抑制神经元的死亡过程有重要作用。
Objective To explore the cytological mechanism of gamma knife treatment of primary epilepsy. Methods The focal cortex model of penicillin in rats was established. The SD rats were randomly divided into experimental group, experimental control group and control group. The peripheral dose was 12 Gy and the isodose curve was 50%. The specimens of cortex and hippocampus in the target area were prepared for light microscopy and conventional transmission electron microscopy samples after 0.5 h to 2 months respectively. Results There were more apoptotic neurons in the epilepsy model rats, while the neurons in the epilepsy model mice were slightly changed at the same time after irradiation with low dose Gamma Knife. Apoptotic cells were rare. Conclusion Apoptosis is involved in the death of hippocampal neurons after penicillin-induced epileptic seizures. Low dose Gamma Knife irradiation may play an important role in inhibiting neuronal death.