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天疱疮类疾病是一组慢性严重的疾患,过去对此类疾患的治疗,均以高量皮质类固醇控制,虽然可以减少死亡率,但大多数患者都要长期用皮质类固醇维持量来控制,往往发生严重的不良反应。自从Beutner等以及Jordon等证明天疱疮类疾病患者血中有循环自家抗体与皮肤基底膜区沉积抗体以来,已被很多临床研究工作者承认为自家免疫性疾患,因此提出应用免疫抑制剂治疗的可能性,并且在实践中收到一定的效果。现就所见之国外资料综述介绍如下:
Pemphigus disease is a group of chronic serious diseases, the treatment of such disorders in the past are high corticosteroid control, although it can reduce the mortality rate, but most patients should be long-term use of corticosteroid maintenance to control, Often serious adverse reactions occur. Since Beutner et al. And Jordon et al. Demonstrated that antibodies against circulating peculiar antibodies and deposition of basal lamina in the skin of patients with pemphigus disease have been recognized by many clinical researchers as autoimmune disorders, immunosuppressive agents have been proposed Possibility, and in practice received some effect. Now see the foreign information summarized as follows: