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目的:观察桑杷二百五汤辅助糖皮质激素对支气管哮喘患者IL-18、IL-33的影响。方法:选取我院2013年9月至2015年9月支气管哮喘患者80例,抽签随机分为观察组与对照组各40例,对照组给予糖皮质激素治疗,观察组给予桑杷二百五汤辅助糖皮质激素治疗。比较两组治疗前后血清白细胞介素IL-18、IL-33、免疫球蛋白(Ig E)水平、咳嗽症状量化评分、肺功能指标及治疗有效率。结果:观察组IL-18、IL-33、Ig E水平显著低于对照组(P<0.05);观察组咳嗽症状量化评分显著低于对照组(P<0.05);观察组肺功能指标显著高于对照组(P<0.05);观察组治疗有效率(97.5%)显著优于对照组(85%)(P<0.05)。结论:桑杷二百五汤辅助糖皮质激素能有效降低支气管哮喘患者IL-18、IL-33的产生,治愈有效率高,有临床应用推广价值。
Objective: To observe the effect of Mulberry two hundred and five soup adjuvant glucocorticoids on IL-18 and IL-33 in patients with bronchial asthma. Methods: Eighty patients with bronchial asthma were selected from September 2013 to September 2015 in our hospital. Randomly divided into observation group and control group, 40 patients in the control group were treated with glucocorticoid. The observation group was given berberine soup Corticosteroid treatment. The levels of serum IL-18, IL-33, IgE, cough symptom score, pulmonary function index and treatment efficiency were compared between the two groups before and after treatment. Results: The levels of IL-18, IL-33 and Ig E in the observation group were significantly lower than those in the control group (P <0.05). The cough symptom score in the observation group was significantly lower than that in the control group (P <0.05) (P <0.05). The effective rate in treatment group (97.5%) was significantly better than that in control group (85%) (P <0.05). Conclusion: Mulberry two hundred and five soup adjuvant glucocorticoids can effectively reduce the production of IL-18 and IL-33 in patients with bronchial asthma, the cure is effective and has clinical application value.