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目的开展晶状体再灌注的离体和动物实验研究,并对再灌注人工晶状体技术进行评价。方法采用新鲜离体幼兔眼、离体猪眼、新西兰白兔眼,应用自行研制的人工晶状体材料,进行以下实验:(1)体外固化实验;(2)晶状体前囊膜微型撕囊及其稳固性实验;(3)经微型前囊膜开口超声乳化吸出晶状体内容物实验;(4)活的新西兰白兔眼内人工晶状体再灌注实验。结果(1)按硅酮聚合物与固化剂50:1的比例可获得柔软、弹性好、固化时间短(完全固化时间为60min)的注入材料;(2)晶状体前囊膜1.8～2.0mm的连续环形撕囊口具有较好的稳定性,可经该微型开口吸出晶状体内容物并灌注材料;(3)超声能量18%、流量25mL·min-1、负压120mmHg(1kPa=7.5mmHg)为晶状体内容物经微型前囊膜开口吸出的最佳条件;(4)注入灌注材料后可形成由晶状体囊膜包裹的、置换原晶状体皮质和核的、新的再灌注人工晶状体。结论采用再灌注人工晶状体的方法可进行新型人工晶状体再灌注,可为治疗白内障和老视提供参考。
Objective To study the in vitro and in vivo experiments of lens reperfusion and to evaluate the technique of reperfusion intraocular lens (IOL). Methods The freshly isolated rabbit eyes, pigs in vitro and New Zealand white rabbits were used to conduct the following experiments: (1) in vitro curing experiment; (2) anterior capsular capsulorhexis and its Stability experiment; (3) phacoemulsification through the mini-anterior capsule opening aspiration of lens contents; (4) live New Zealand white rabbit intraocular lens reperfusion experiment. Results (1) According to the ratio of silicone polymer and curing agent 50: 1, soft, good elasticity and short curing time (complete curing time 60min) can be obtained; (2) (3) 18% ultrasonic energy, 25mL · min-1 flow rate, 120mmHg negative pressure (1kPa = 7.5mmHg) is (4) The injection of the infusion material can form a new reperfusion intraocular lens encircled by the lens capsule, replacing the original lens cortex and nucleus. Conclusion Reperfusion intraocular lens (IOL) can be used to reperfusion a new type of intraocular lens (IOL), which can provide reference for the treatment of cataract and presbyopia.