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采用逆相蒸发法制备稳定的白细胞介素２（ＩＬ－２）大单层脂质体，对其包封率、稳定性进行了测定。建立Ｃ５７ＢＬ／６小鼠荷瘤动物模型，通过给荷瘤小鼠腹腔注射空白脂质体、单纯ＩＬ－２及ＩＬ－２脂质体来比较其在肿瘤生长中的抑制作用。结果是空白脂质体组抑瘤率为４．３％，单纯ＩＬ－２和脂质体ＩＬ－２的抑瘤率分别为３４．０％和５４．６％。空白脂质体组与单纯对照组相比差异无显著性（Ｐ＞０．０５），脂质体ＩＬ－２组与单纯ＩＬ－２组之间差异有显著性（Ｐ＜０．０５），脂质体ＩＬ－２的抑瘤率比单纯ＩＬ－２抑瘤率提高了２０．６％。
The stable monolayer of interleukin 2 (IL-2) was prepared by reverse phase evaporation method, and its encapsulation efficiency and stability were determined. The animal model of C57BL / 6 mice was established. The inhibition of tumor growth was evaluated by intraperitoneal injection of blank liposomes, IL-2 alone and IL-2 liposomes. As a result, the inhibition rate of the blank liposome group was 4.3%, the inhibition rates of the pure IL-2 and liposome IL-2 were 34.0% and 54.6%, respectively. There was no significant difference between blank liposome group and control group (P> 0.05), but there was significant difference between liposome IL-2 group and IL-2 alone group (P <0.05) The inhibition rate of liposome IL-2 was 20.6% higher than that of IL-2 alone.