Hepatitis B virus induces expression of cholesterol metabolism-related genes via TLR2 in HepG2 cells

• 作 者: Ying-Ju Li Ping Zhu Yu Liang W
• 机 构: InstituteofPathogenicBiology,DepartmentofInfectiousDiseases,GuangdongCardiovascularInstitute
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2013年14期
• 关键词: Hepatitis B virus TOLL-LIKE receptors Lowdensity LIPOPROTEIN receptor 3-hydroxy-
• 基金项目: Supported by The Youth Foundation of Hunan Provincial Education Department,No.11B110,the Graduate Innovation Project of Hunan Provincial Education Department,No.CX2010B382

AIM:To investigate whether hepatitis B virus(HBV) exacerbates hepatic cholesterol accumulation,and explore the underlying mechanisms.METHODS:HepG2 cells were infected with adenovirus(Ad) containing 1.3-fold overlength HBV genome.Realtime polymerase chain