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目的评估FPG与胰岛β细胞功能及IS之间的关系。方法采用多阶段分层整群随机抽样方法对江苏省1277例人群进行研究,根据OGTT分为NGT、IFG、IGT、IGR、T2DM组。IS用ISI及1/HOMA-IR评价;β细胞功能用经IS校正的处置指数DI(包括DI0、DI30、DI120)评估。结果同NGT组ISI、DI0、DI30、DI120相比,IGT组分别下降25.2%、17.1%、37.2%、12.5%;IFG组分别下降23.5%、65.4%、37.6%、37.1%;IGR组分别下降42.7%、70.1%、56.5%、38.1%;T2DM组分别下降44.7%、83.4%、76.0%、66.0%。结论在正常糖耐量阶段,随着FPG升高,IS和胰岛素分泌有下降趋势,两者共同促进FPG的升高。
Objective To assess the relationship between FPG and islet β cell function and IS. Methods The multi-stage stratified cluster random sampling method was used to study 1277 people in Jiangsu Province. According to OGTT, they were divided into NGT, IFG, IGT, IGR and T2DM groups. IS was evaluated using ISI and 1 / HOMA-IR; β-cell function was assessed using IS-corrected treatment indices DI (including DI0, DI30, DI120). Results The levels of IGT were decreased by 25.2%, 17.1%, 37.2% and 12.5% in the IGT group compared with the ISI, DI0, DI30 and DI120 groups in the NGT group, and decreased by 23.5%, 65.4%, 37.6% and 37.1% 42.7%, 70.1%, 56.5% and 38.1%, respectively. The T2DM group decreased by 44.7%, 83.4%, 76.0% and 66.0% respectively. Conclusions In normal glucose tolerance stage, IS and insulin secretion have a decreasing trend with the increase of FPG, both of which can promote the increase of FPG.