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转移因子(TF)作为细胞免疫增强剂,对恶性肿瘤患者的辅助治疗有一定的疗效,但对肿瘤细胞的生长繁殖有无直接抑制或杀灭作用报道甚少。近来报道:特异性TF(S-TF)低浓度时可以抑制癌细胞RNA和蛋白质的合成,增加细胞内cAMP含量,降低cGMP/cAMP比值。S-TF对肿瘤细胞DNA的合成是否有调节作用,迄今尚未见报道。 我们以小鼠H_(22)腹水癌细胞作为免疫
Transfer factor (TF) as a cellular immune enhancer has a certain effect on the adjuvant treatment of malignant tumor patients, but there is little report on the direct inhibition or killing effect on tumor cell growth and reproduction. Recently, it has been reported that specific TF (S-TF) can inhibit the synthesis of RNA and protein in cancer cells, increase the intracellular cAMP content, and reduce the cGMP/cAMP ratio. Whether S-TF regulates the synthesis of DNA in tumor cells has not been reported so far. We used mouse H_(22) ascites cancer cells as immunity