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目的观察分析小儿癫痫治疗中联合应用托吡酯与丙戊酸钠的临床疗效。方法 120例小儿癫痫患儿,随机将其分为托吡酯组、丙戊酸钠组和联合组(托吡酯联合丙戊酸钠),各40例,对三组患儿的治疗效果与不良反应发生情况进行观察比较。结果联合组治疗总有效率(95.0%)高于托吡酯组(72.5%)和丙戊酸钠组(80.0%),差异具有统计学意义(P<0.05)。联合组不良反应发生率(10.0%)低于托吡酯组(27.5%)和丙戊酸钠组(30.0%),差异具有统计学意义(P<0.05)。结论托吡酯联合丙戊酸钠治疗小儿癫痫患儿具有显著的疗效,且患儿未发生较多的不良反应,值得临床进一步推广使用。
Objective To observe the clinical effect of combined use of topiramate and valproate in the treatment of pediatric epilepsy. Methods A total of 120 children with epilepsy were randomly divided into topiramate group, sodium valproate group and combination group (Topiramate plus sodium valproate), 40 cases in each group. The therapeutic effects and adverse reactions of the three groups were compared Observe and compare. Results The total effective rate (95.0%) in the combination group was significantly higher than that in the topiramate group (72.5%) and sodium valproate group (80.0%) (P <0.05). The incidence of adverse reactions (10.0%) in the combination group was lower than that in the topiramate group (27.5%) and the sodium valproate group (30.0%), with statistical significance (P <0.05). Conclusion Topiramate combined with sodium valproate in children with epilepsy has a significant effect, and children did not occur more adverse reactions, it is worth further clinical use.