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目的:探讨测定尿液中血管抑素及VEGF在妇科肿瘤诊断方面的价值。方法:选择妇科恶性肿瘤患者32例(恶性肿瘤组)、31例妇科良性肿瘤患者(良性肿瘤组)及25例健康妇女(正常组),用赖氨酸-ELISA法测定三组尿液中的血管抑素水平,同时ELISA法测定恶性肿瘤组及正常组尿液中VEGF水平。结果:妇科恶性肿瘤组尿血管抑素水平(中位水平为2.06)高于正常组及良性肿瘤组(中位水平为0.70及0.80),差异有统计学意义(P<0.05);正常组与良性肿瘤组尿血管抑素水平相比,差异无统计学意义(P>0.05)。妇科恶性肿瘤组尿VEGF水平略高于正常组,但两组相比,差异无统计学意义(P>0.05)。结论:测得尿液中血管抑素水平有望作为妇科恶性肿瘤诊断及良恶性预测的指标之一。尿液中VEGF水平可能不是协助早期诊断妇科恶性肿瘤的合适指标。
Objective: To investigate the value of determination of angiostatin and VEGF in the diagnosis of gynecological tumors. Methods: Thirty-two patients with malignant tumor (malignant tumor group), 31 patients with benign gynecologic tumor (benign tumor group) and 25 healthy women (normal group) were enrolled in this study. The urine of three groups The level of angiostatin in the urine of patients with malignant tumor and normal group was detected by ELISA. Results: The level of urinary angiostatin in gynecologic malignant tumors was significantly higher than that in normal and benign tumors (median, 0.70 and 0.80, respectively, 2.06) (P <0.05) There was no significant difference in the level of urinary angiostatin between benign and malignant tumors (P> 0.05). The level of urinary VEGF in gynecological malignant tumor group was slightly higher than that in normal group, but there was no significant difference between the two groups (P> 0.05). Conclusion: The measured level of angiostatin in urine is expected to be one of the prognostic indicators for gynecologic malignancies. Urinary VEGF levels may not be a good indicator of early diagnosis of gynecological malignancies.