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目的探讨癫癎患者认知功能障碍及其影响因素。方法采用韦氏儿童智力量表及成人智力量表对125例癫癎患者的认知功能进行测定,并分析年龄、发作类型、癫癎综合征类型、病因、发作频率、严重程度、脑电图改变、服用药物及家族史等因素对其的影响。结果癫癎患者认知功能障碍发生率为18.4%,儿童(27.8%)高于成人(14.6%)。癫癎组儿童和成人患者总智商(FIQ)、操作智商(PIQ)和言语智商(VIQ)、言语理解因子(VCF)、知觉组织因子(POF)和记忆/注意不分心因子(MF)显著低于相应的正常对照组(均P<0.01)。多因素回归分析显示,发作程度越严重、服用药物的数量越多,智商越低,全面发作对智商的影响最明显。结论癫癎患者存在明显的认知功能障碍,发作严重程度、服药数量,发作形式是影响其认知功能的独立危险因素。
Objective To investigate the cognitive dysfunction and its influencing factors in patients with epilepsy. Methods The cognitive function of 125 patients with epilepsy was measured by Wechsler Children Intelligence Scale and Adult Intelligence Scale. The age, type of seizure, type of epilepsy, etiology, seizure frequency, severity, EEG Change, taking drugs and family history and other factors on its impact. Results The incidence of cognitive impairment in epileptic patients was 18.4% and in children (27.8%) was higher than that in adults (14.6%). FIQ, VIQ, VCF, POF and MF in children and adults with epilepsy group were significantly higher than those in control group Lower than corresponding normal control group (all P <0.01). Multivariate regression analysis showed that the more serious the seizures, the more the amount of medication taken, the lower the IQ, and the full impact on IQ was the most obvious. Conclusion There are obvious cognitive dysfunction in epilepsy patients. The severity of seizure, medication dosage and the type of seizure are independent risk factors affecting their cognitive function.