论文部分内容阅读
目的探讨无创DNA产前检测技术对单项超声软指标孕妇筛查胎儿染色体异常的临床价值。方法选取福建医科大学附属漳州市医院和广州医科大学附属第三医院2013-2015年孕期(≥12周)检查提示胎儿超声单项软指标阳性的病例1 076例均接受产前无创DNA检测,对筛查阳性病例再次行绒毛活检或羊水穿刺查染色体核型确诊。结果 1 076例胎儿中无创DNA提示高风险16例,阳性率1.5%;核型确诊异常15例,假阳性率6.25%。结论无创DNA产前检测技术可作为准确性较高的筛查方法,运用于单项超声软指标胎儿染色体检查获得满意结果,可减少介入性检查,避免流产、感染等风险。
Objective To investigate the clinical value of noninvasive DNA prenatal detection in screening fetus chromosomal abnormalities in single ultrasound soft index pregnant women. Methods A total of 1 076 cases of positive fetal soft-labeled fetuses in Zhangzhou City Hospital affiliated to Fujian Medical University and the Third Affiliated Hospital of Guangzhou Medical University during 2013-2015 (≥12 weeks) were selected for prenatal noninvasive DNA testing. Check positive cases again villus biopsy or amniocentesis check the chromosome karyotype confirmed. Results The noninvasive DNA in 1 076 fetuses was found to be highly risky in 16 cases, the positive rate was 1.5%. The abnormal karyotype was found in 15 cases and the false positive rate was 6.25%. Conclusion Noninvasive DNA prenatal testing can be used as a more accurate screening method. It can be used to obtain satisfactory results in single ultrasonography of fetal fetal chromosomes, which can reduce the risk of miscarriage and infection.