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随着生活方式的改变及人类寿命的延长，乳腺癌发病率逐年上升。乳腺癌在早期即会发生全身性微小转移，造成２／３的病人在首次治疗后５年内复发。目前国内对乳腺癌复发的治疗仍以联合化疗为主，尤其是含息环类药物及泰素、长春新碱类等作用强烈的化合物。联合化疗的近期缓解率
With changes in lifestyle and human life expectancy, the incidence of breast cancer increased year by year. Breast cancer undergoes systemic micrometastases at an early stage, causing 2/3 of patients to relapse within 5 years of the first treatment. At present, the treatment of breast cancer recurrence is still mainly combined with chemotherapy, especially with the ring-containing drugs and taxol, vincristine and other strong compounds. Recent remission rate of combination chemotherapy