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目的比较3种口服降糖药(OAD)对T2DM患者机体水溶性维生素水平的影响。方法将80例T2DM住院患者分为4组,每组20例,于住院前及住院第5天检测FPG、2hPG,血清及尿VB1、VB6、VB12、VC和叶酸水平。结果各组FPG治疗后较治疗前下降(P<0.05)。各组间FPG变化值比较差异有统计学意义(P<0.05)。各组2hPG治疗后较治疗前下降(P<0.05)。各组间2hPG变化值比较差异有统计学意义(P<0.05)。A、C、D组血清VB1、VB6、VB12、VC和叶酸水平治疗后较治疗前降低(P<0.05),B组治疗前后比较差异无统计学意义,各组间变化值比较差异无统计学意义。各组尿VB1、VB6、VB12、VC和叶酸水平治疗前后比较差异有统计学意义(P<0.05),各组间变化值比较差异无统计学意义。结论 OAD治疗T2DM时应注意二甲双胍和阿卡波糖对水溶性维生素的影响。
Objective To compare the effects of three oral hypoglycemic agents (OADs) on the water-soluble vitamins in T2DM patients. Methods Eighty patients with T2DM were divided into 4 groups with 20 patients in each group. FPG, 2hPG, serum and urine VB1, VB6, VB12, VC and folic acid levels were measured before hospitalization and 5 days after hospitalization. Results The FPG of each group decreased after treatment (P <0.05). The differences of FPG in each group were statistically significant (P <0.05). The 2hPG treatment decreased in all groups after treatment (P <0.05). The changes of 2hPG in each group had statistical significance (P <0.05). The serum levels of VB1, VB6, VB12, VC and folic acid in groups A, C and D were lower than those before treatment (P <0.05), but there was no significant difference between before and after treatment in group B significance. There were significant differences in the levels of VB1, VB6, VB12, VC and folic acid before and after treatment between the two groups (P <0.05). There was no significant difference in the changes among the groups. Conclusion The effect of metformin and acarbose on water-soluble vitamins should be noticed in the treatment of T2DM with OAD.